RAF Typhoon FGR4s have joined forces with France's air force in a joint strike against an underground arms cache in Syrian territory operated by the Daesh militant organization, per a report from the UK's MoD.
The facility, identified by intelligence, was believed to be storing arms and explosives, the statement said, and was situated in hills just north of the historic site of Palmyra in the heart of Syria.
"Our fighter planes employed laser-guided Paveway IV weapons to hit a number of approach shafts leading to the depot... preliminary assessments suggest the objective was successfully hit," the MoD said.
There was no evidence of any civilian casualties in the attack late on Saturday and all the aircraft returned safely, the ministry further stated.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as ISIS - enforced extremist governance over parts of both Syria and Iraq before its territorial defeat in 2019.
"This strike underscores British leadership, and resolve to work closely with our allies, to eradicate any revival of the terrorist group and their violent and radical beliefs in the region," UK Defence Secretary John Healey stated.
RAF aircraft have carried out overwatch operations over Syrian airspace to "prevent any attempted resurgence" of IS following its defeat at the Baghuz confrontation in 2019, the ministry said.
"I extend gratitude to the personnel of the UK armed forces who took part in this operation for their skill and their valour," he added. "Including them were a great many British personnel on duty over Christmas and New Year. This action, to take out militants who endanger our way of life, demonstrates how UK forces are ready to step up, throughout the year, keeping Britain secure within its borders and strong abroad."
Last December, the United States armed forces carried out what it termed a "major assault" on IS targets in the country, after an ambush claimed the lives of two US servicemembers and a civilian linguist in Palmyra.
The United Nations says IS still boasts between 5,000 and 7,000 militants in Syria and Iraq.